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KMID : 1144320100420020107
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감염과 화학요법
2010 Volume.42 No. 2 p.107 ~ p.111
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A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009) in a Patient with Acute Myeloid Leukemia
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Lee Yo-Han
Kim Hyo-Youl
Kim Hyun-Soo
Uh Young
Kim Young-Keun
Kim Bo-Ra
Jung Ho-Yeon
Kim Woo-Taek
Yi Hwa-Jung
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Abstract
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Oseltamivir is the drug of choice for patients with pandemic influenza (H1N1 2009). However, sporadic cases of oseltamivir resistance have been described worldwide. Up to March 2010, a total of 11 strains (2.2% of tested isolates) of oseltamivirresistant pandemic influenza (H1N1 2009) have been discovered in South Korea. We report a case of 46-year-old man with acute myeloid leukemia in whom an oseltamivir-resistant pandemic (H1N1) 2009 virus was isolated. Despite high dose oseltamivir therapy for 10 days he had persistent symptoms and showed positive results in repeated real-time RT-PCR for pandemic influenza (H1N1 2009) virus from nasopharyngeal specimen. The patient improved eventually after oseltamivir was replaced by zanamivir inhalation.
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KEYWORD
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Pandemic influenza (H1N1 2009), Oseltamivir, Antiviral resistance, Leukemia
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